FKBP8 抗体
Quick Overview for FKBP8 抗体 (ABIN5697691)
抗原
See all FKBP8 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- FKBP8 antibody
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免疫原
- FK506 binding protein 8, 38kDa
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- FKBP8 (FK506 Binding Protein 8, 38kDa (FKBP8))
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别名
- FKBP8
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背景
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Synonyms: Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8)|38 kDa FK506-binding protein (38 kDa FKBP, FKBP-38, hFKBP38)|FK506-binding protein 8 (FKBP-8)|FKBPR38|Rotamase|FKBP8|FKBP38
Background: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
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分子量
- 53 kDa
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基因ID
- 23770
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UniProt
- Q14318
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途径
- Autophagy
抗原
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