PKM1 抗体
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- 抗原
- PKM1
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- 非结合性
- 应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)
- 免疫原
- PKM2 pyruvate kinase, muscle
- 亚型
- IgG
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anti-PKM1 (AA 383-417), (C-Term) antibody
适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB18404 unconjugated
anti-PKM1 antibody适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-PKM1 antibody适用: 人 WB 宿主: 小鼠 Monoclonal OTI3C6 unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with FNab06494(PKM1-specific) at dilution of 1:1500
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze / thaw cycles.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- PKM1
- 背景
- Synonyms:CTHBP, OIP 3, OIP3, Opa interacting protein 3, p58, PK2, PK3, PKM, PKM1, PK-M1, PKM1 pyruvate kinase, muscle, Pyruvate kinase 2/3, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle isozyme, TCB, THBP1, Tumor M2 PK Background:PKM, also named as OIP3, PK2, PK3, PKM, p58, THBP1, CTHBP and Tumor M2-PK, belongs to the pyruvate kinase family. It is glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate(PEP) to ADP, generating ATP. It stimulates POU5F1-mediated transcriptional activation. PKM plays a general role in caspase independent cell death of tumor cells. PKM has 2 isoforms named PKM1 and PKM2. By the upstream metabolite fructose-1,6-bisphosphate, PKM1 is a constitutively active enzyme.The primary pyruvate kinase isoform before tumour development is PK-M1, however, the primary isoform from four independent tumours is PK-M2(PMID:18337823). This antibody is specific to PKM1 isoform.
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