PKM1 (AA 383-417), (C-Term) 抗体
适用: 人, 小鼠
WB, IHC (p)
宿主: 兔
Polyclonal
RB18404
unconjugated
(6 references)-
- 抗原
- PKM1
- 抗原表位
- AA 383-417, C-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- 非结合性
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This PKM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-417 amino acids from the C-terminal region of human PKM1.
- 克隆位点
- RB18404
- 亚型
- Ig Fraction
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anti-PKM1 antibody
适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-PKM1 antibody适用: 人 WB 宿主: 小鼠 Monoclonal OTI3C6 unconjugated
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- 应用备注
- WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
-
-
: "Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 21, Issue 22, pp. 5110-20, (2015) (PubMed).
: "Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 43, pp. 15526-31, (2014) (PubMed).
: "Hypoxic stress induces, but cannot sustain trophoblast stem cell differentiation to labyrinthine placenta due to mitochondrial insufficiency." in: Stem cell research, Vol. 13, Issue 3 Pt A, pp. 478-91, (2014) (PubMed).
: "Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 18, pp. 6904-9, (2012) (PubMed).
: "Enhancing mitochondrial respiration suppresses tumor promoter TPA-induced PKM2 expression and cell transformation in skin epidermal JB6 cells." in: Cancer prevention research (Philadelphia, Pa.), Vol. 4, Issue 9, pp. 1476-84, (2011) (PubMed).
: "Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 10, pp. 4129-34, (2011) (PubMed).
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: "Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 21, Issue 22, pp. 5110-20, (2015) (PubMed).
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- 抗原
- PKM1
- 背景
- PKM1 is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. The protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis.
- 分子量
- 57937
- 基因ID
- 5315
- NCBI登录号
- NP_001193725, NP_001193726, NP_001193727, NP_001193728, NP_002645, NP_872270, NP_872271
- UniProt
- P14618
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