PKM1 抗体
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北京 101111
Quick Overview for PKM1 抗体 (ABIN5697233)
抗原
适用
宿主
克隆类型
标记
应用范围
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原理
- PKM1-specific antibody
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免疫原
- peptide
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亚型
- IgG
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anti-PKM1 (AA 383-417), (C-Term) antibody
适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB18404 unconjugated
anti-PKM1 antibody适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-PKM1 antibody适用: 人 WB 宿主: 小鼠 Monoclonal OTI3C6 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with FNab06494(PKM1-specific) at dilution of 1:1500
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- PKM1
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背景
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Synonyms: PKM1|PK-M1|PKM1 pyruvate kinase|muscle|PKM|Pyruvate kinase PKM
Background: PKM, also named as OIP3, PK2, PK3, PKM, p58, THBP1, CTHBP and Tumor M2-PK, belongs to the pyruvate kinase family. It is glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate(PEP) to ADP, generating ATP. It stimulates POU5F1-mediated transcriptional activation. PKM plays a general role in caspase independent cell death of tumor cells. PKM has 2 isoforms named PKM1 and PKM2. By the upstream metabolite fructose-1,6-bisphosphate, PKM1 is a constitutively active enzyme.The primary pyruvate kinase isoform before tumour development is PK-M1, however, the primary isoform from four independent tumours is PK-M2(PMID:18337823). This antibody is specific to PKM1 isoform.
抗原
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