ALIX 抗体
Quick Overview for ALIX 抗体 (ABIN5696923)
抗原
See all ALIX (PDCD6IP) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PDCD6IP antibody
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免疫原
- programmed cell death 6 interacting protein
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))
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别名
- PDCD6IP
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背景
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Synonyms: Programmed cell death 6-interacting protein (PDCD6-interacting protein)|ALG-2-interacting protein 1|ALG-2-interacting protein X|Hp95|PDCD6IP|AIP1|ALIX|KIAA1375
Background: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.
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基因ID
- 10015
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UniProt
- Q8WUM4
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途径
- p53 Pathway, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation
抗原
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