PROX1 抗体 (C-Term)
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Quick Overview for PROX1 抗体 (C-Term) (ABIN569679)
抗原
See all PROX1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody is reactive with Prox-1. It will be a useful tool to study lymphatic vessel density in and around human tumors. It will detect Prox-1 in the nucleus of lymphatic endothelial cells.
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纯化方法
- Purified
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免疫原
- Peptide corresponding to the Homeobox domain of Prox1.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C/-80 °C
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储存方法
- Store lyophilized (preferably in a desiccator) at -20 °C and in aliquots at -80 °C. Reconstituted antibody can be stored at 4 °C for a limited period of time, it does not show decline in activity after two weeks at 4 °C.
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- PROX1 (Prospero Homeobox 1 (PROX1))
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别名
- PROX-1
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背景
- The homeobox gene Prox-1 was originally cloned by homology to the Drosophila melanogaster gene prospero. Prox-1 is expressed in a subpopulation of endothelial cells which by budding and sprouting, give rise to the lymphatic system. Prox-1-deficient homozygous mice have unaffected vasculogenesis and angiogenesis, but liver and lymphatics do not develop. Human Prox-1 gene has been mapped to chromosome 1q32.2-q32.3, and its product shows 94 % similarity to the chicken protein. The conserved structure and expression pattern of the Prox-1 gene imply that it may play the same roles in humans as in other vertebrates. The human Prox-1 gene is most actively expressed in the developing lens. Anti-Prox-1 antibodies provide a highly specific marker of lymphatic endothelial cells.Synonyms: Homeobox prospero-like protein PROX1, PROX1, Prospero homeobox protein 1
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基因ID
- 5629
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NCBI登录号
- NP_002754
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UniProt
- Q92786
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途径
- Stem Cell Maintenance, Regulation of Muscle Cell Differentiation
抗原
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