Isocitrate Dehydrogenase 抗体 (Internal Region)
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Quick Overview for Isocitrate Dehydrogenase 抗体 (Internal Region) (ABIN569649)
抗原
See all Isocitrate Dehydrogenase (IDH) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 65-77, Internal Region
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序列
- KKHNVGVKCA TIT
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特异性
- Recognizes IDH1 (65-77).
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交叉反应 (详细)
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Species reactivity (expected):Canine (Dog), Sheep.
Species reactivity (tested):Human, Mouse, Rat. -
纯化方法
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
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免疫原
- Peptide with sequence from the internal region of the protein sequence according to NP_005887.2.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Isocitrate Dehydrogenase (IDH)
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别名
- Isocitrate Dehydrogenase / IDH
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背景
- IDH1 belongs to two distinct subclasses. The protein is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. This protein contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.Synonyms: Cytosolic NADP-isocitrate dehydrogenase, ICDH, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, PICD, cytoplasmic Isocitrate dehydrogenase [NADP]
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分子量
- 46.7kDa (NP_005887.2).
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基因ID
- 3417
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NCBI登录号
- NP_005887
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UniProt
- O75874
抗原
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