PUMA 抗体 (Internal Region)
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- 抗原 See all PUMA (BBC3) 抗体
- PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
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抗原表位
- Internal Region
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适用
- 人
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宿主
- 山羊
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克隆类型
- 多克隆
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标记
- This PUMA antibody is un-conjugated
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应用范围
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- 序列
- C-DGGRPQRTVR
- 特异性
- This antibody is expected to recognize isoform 1 (NP_001120712.1) only.
- 交叉反应 （详细）
- Species reactivity (tested):Human.
- 纯化方法
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
- 免疫原
- Peptide with sequence from the internal region of the protein sequence according to NP_001120712.1.
- Top Product
- Discover our top product BBC3 Primary Antibody
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anti-BCL2 Binding Component 3 (BBC3) antibody
BBC3 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (C-Term) antibodyBBC3 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 131-180) antibodyBBC3 适用: 人, 大鼠, Pig WB, ELISA, FACS, IP, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 119-154) antibodyBBC3 适用: 人 WB, ELISA, IHC, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (N-Term) antibodyBBC3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (C-Term) antibody (PE)BBC3 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal PE
anti-BCL2 Binding Component 3 (BBC3) (C-Term) antibody (PerCP)BBC3 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal PerCP
anti-BCL2 Binding Component 3 (BBC3) (AA 119-154) antibodyBBC3 适用: 人 WB, FACS, IHC (p), IF 宿主: 兔 Polyclonal RB01353 unconjugated
anti-BCL2 Binding Component 3 (BBC3) (N-Term) antibody (Biotin)BBC3 适用: 人 WB, IHC 宿主: 兔 Polyclonal Biotin
anti-BCL2 Binding Component 3 (BBC3) (BH3 Domain), (C-Term) antibodyBBC3 适用: 人, 小鼠 WB, FACS, IHC (p), IF, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
- 别名
- PUMA (BBC3 产品)
- 别名
- BBC3 antibody, Puma antibody, JFY-1 antibody, JFY1 antibody, PUMA antibody, PUMA/JFY1 antibody, BCL2 binding component 3 antibody, Bcl-2 binding component 3 antibody, BBC3 antibody, Bbc3 antibody, bbc3 antibody
- 背景
- Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-alpha and PUMA-beta. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.Synonyms: BBC3, Bcl-2-binding component 3, JFY-1, p53 up-regulated modulator of apoptosis
- 分子量
- 26.5kDa (NP_001120712.1).
- 基因ID
- 27113
- NCBI登录号
- NP_001120712
- UniProt
- Q9BXH1
- 途径
- p53 Pathway, Positive Regulation of Endopeptidase Activity
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