Prothrombin 抗体 (AA 67-124)
(1 reference)Quick Overview for Prothrombin 抗体 (AA 67-124) (ABIN5693261)
抗原
See all Prothrombin (F2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 67-124
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原理
- Anti-Prothrombin/F2 Antibody Picoband®
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品牌
- Picoband™
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Rabbit IgG polyclonal antibody for Prothrombin detection. Tested with WB, IHC-P, Direct ELISA in Human.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E. coli-derived human Prothrombin recombinant protein (Position: Y67-R124).
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亚型
- IgG
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anti-Coagulation Factor II (thrombin) (F2) (AA 263-362) antibody
F2 适用: 人 WB, IP, ELISA, RNAi, PLA 宿主: 小鼠 Monoclonal 1B7 unconjugated
anti-Coagulation Factor II (thrombin) (F2) (AA 324-617) antibodyF2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) (F2) (AA 44-200) antibodyF2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) (F2) (Middle Region) antibodyF2 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 绵羊, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) (F2) antibodyF2 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal E1 unconjugated
anti-Coagulation Factor II (thrombin) (F2) (AA 44-200) antibodyF2 适用: 大鼠 WB 宿主: 小鼠 Monoclonal C10 unconjugated
anti-Coagulation Factor II (thrombin) (F2) (Internal Region) antibodyF2 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) (F2) (AA 1-622) antibodyF2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) (F2) (N-Term) antibodyF2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) (F2) (AA 201-323) antibodyF2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL
Immunocytochemistry, 0.5-1 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x106 cells
ELISA, 0.1-0.5 μg/mL
1. Lancellotti, S., De Cristofaro, R. Congenital prothrombin deficiency. Semin. Thromb. Hemost. 35: 367-381, 2009. 2. Royle, N. J., Irwin, D. M., Koschinsky, M. L., MacGillivray, R. T. A., Hamerton, J. L. Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively. Somat. Cell Molec. Genet. 13: 285-292, 1987. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Heparin impairs angiogenesis through inhibition of microRNA-10b." in: The Journal of biological chemistry, Vol. 286, Issue 30, pp. 26616-27, (2011) (PubMed).
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: "Heparin impairs angiogenesis through inhibition of microRNA-10b." in: The Journal of biological chemistry, Vol. 286, Issue 30, pp. 26616-27, (2011) (PubMed).
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- Prothrombin (F2) (Coagulation Factor II (thrombin) (F2))
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别名
- F2
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背景
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Synonyms: Prothrombin, Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain, F2
Tissue Specificity: Expressed by the liver and secreted in plasma.
Background: F2 (Coagulation Factor II), also known as thrombin, is a serine protease that in humans is encoded by the F2 gene. This gene for human prothrombin (F2) was assigned to chromosome 11p11-q12 by analysis of a panel of somatic cell hybrid DNAs and by in situ hybridization, using both cDNA and genomic probes. The activated thrombin enzyme plays an important role in hemostasis and thrombosis: it converts fibrinogen to fibrin for blood clot formation, stimulates platelet aggregation, and activates coagulation factors V, VIII (F8), and XIII (F13A1). Thrombin also inhibits coagulation by activating protein C.
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分子量
- 85 kDa
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UniProt
- P00734
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途径
- Complement System, Peptide Hormone Metabolism, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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