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GCK 抗体 (AA 234-431)

This anti-GCK antibody is a 兔多克隆 antibody detecting GCK in WB 和 ELISA. Suitable for 人, 小鼠和大鼠.

Western blot analysis of Glucokinase using anti-Glucokinase antibody . (GCK 抗体 (AA 234-431))

1 image

产品编号 ABIN5693231

发货至: 中国

Quick Overview for GCK 抗体 (AA 234-431) (ABIN5693231)

抗原

See all GCK 抗体

GCK (Glucokinase (Hexokinase 4) (GCK))

适用

63
22
21
3
2
1
1
1
1
1
1

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

47
5
2
2
2
2
2
2
2
2
2
2

This GCK antibody is un-conjugated

应用范围

56
33
26
12
10
9
6
2
2
1
1

Western Blotting (WB), ELISA

Discover our top product GCK Primary Antibody

抗原表位
8

8

6

4

4

2

1

1

1

1

1

1

1

1

1

1
AA 234-431

原理

Anti-Glucokinase/GCK Antibody Picoband®

交叉反应（详细）

No cross-reactivity with other proteins.

产品特性

Anti-Glucokinase/GCK Antibody Picoband® (ABIN5693231). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

免疫原

E. coli-derived human Glucokinase recombinant protein (Position: Y234-T431).

亚型

IgG
anti-Glucokinase (Hexokinase 4) (GCK) (AA 1-465) antibody
GCK 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Glucokinase (Hexokinase 4) (GCK) antibody
GCK 适用: 人 ELISA 宿主: 小鼠 Monoclonal 4G6 unconjugated

anti-Glucokinase (Hexokinase 4) (GCK) (AA 101-200) antibody
GCK 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated

anti-Glucokinase (Hexokinase 4) (GCK) (AA 3-226) antibody
GCK 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Glucokinase (Hexokinase 4) (GCK) (AA 1-300) antibody
GCK 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Glucokinase (Hexokinase 4) (GCK) antibody
GCK 适用: 人, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Glucokinase (Hexokinase 4) (GCK) (AA 1-465) antibody
GCK 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-Glucokinase (Hexokinase 4) (GCK) (AA 1-465) antibody
GCK 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-Glucokinase (Hexokinase 4) (GCK) (AA 194-410) antibody
GCK 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Glucokinase (Hexokinase 4) (GCK) (N-Term) antibody
GCK 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Gloyn, A. L. Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy.Hum. Mutat. 22: 353-362, 2003. 2. Grimsby, J., Sarabu, R., Corbett, W. L., Haynes, N.-E., Bizzarro, F. T., Coffey, J. W., Guertin, K. R., Hilliard, D. W., Kester, R. F., Mahaney, P. E., Marcus, L., Qi, L., Spence, C. L., Tengi, J., Magnuson, M. A., Chu, C. A., Dvorozniak, M. T., Matschinsky, F. M., Grippo, J. F. Allosteric activators of glucokinase: potential role in diabetes therapy. Science 301: 370-373, 2003.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
抗原

GCK (Glucokinase (Hexokinase 4) (GCK))

别名

GCK

背景

Synonyms: Glucokinase, Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D, GCK
Tissue Specificity: Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver.
Background: Glucokinase (GCK) is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

分子量

52 kDa

基因ID

2645

UniProt

P35557

途径

MAPK Pathway, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process

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