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TPX2 抗体 (AA 15-93)

This anti-TPX2 antibody is a 兔 多克隆 antibody detecting TPX2 in WB 和 ELISA. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN5693144
发货至: 中国

Quick Overview for TPX2 抗体 (AA 15-93) (ABIN5693144)

抗原

See all TPX2 抗体
TPX2 (TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This TPX2 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA
  • 抗原表位

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    AA 15-93

    原理

    Anti-TPX2 Antibody Picoband®

    交叉反应 (详细)

    No cross-reactivity with other proteins.

    产品特性

    Anti-TPX2 Antibody Picoband® (ABIN5693144). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    免疫原

    E. coli-derived human TPX2 recombinant protein (Position: D15-Q93).

    亚型

    IgG
  • 应用备注

    Western blot, 0.1-0.5 μg/mL
    ELISA, 0.1-0.5 μg/mL
    1. Gruss, O. J., Wittmann, M., Yokoyama, H., Pepperkok, R., Kufer, T., Sillje, H., Karsenti, E., Mattaj, I. W., Vernos, I. Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells. Nature Cell. Biol. 4: 871-879, 2002. 2. Kufer, T. A., Sillje, H. H. W., Korner, R., Gruss, O. J., Meraldi, P., Nigg, E. A. Human TPX2 is required for targeting Aurora-A kinase to the spindle. J. Cell Biol. 158: 617-623, 2002.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • 抗原

    TPX2 (TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2))

    别名

    TPX2

    背景

    Synonyms: Targeting protein for Xklp2, Differentially expressed in cancerous and non-cancerous lung cells 2, DIL-2, Hepatocellular carcinoma-associated antigen 519, Hepatocellular carcinoma-associated antigen 90, Protein fls353, Restricted expression proliferation-associated protein 100, p100, TPX2, C20orf1, C20orf2, DIL2, HCA519

    Tissue Specificity: Expressed in lung carcinoma cell lines but not in normal lung tissues.

    Background: Targeting protein for Xklp2, also known as C20ORF1, is a protein that in humans is encoded by the TPX2 gene. It is mapped to chromosome 20q11.2. It was concluded that even in the presence of duplicated centrosomes, spindle formation requires the function of TPX2 to generate a stable bipolar spindle with overlapping antiparallel microtubule arrays. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.

    分子量

    86 kDa, 100 kDa

    基因ID

    22974
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