ICOS 抗体 (AA 21-140)
Quick Overview for ICOS 抗体 (AA 21-140) (ABIN5693002)
抗原
See all ICOS 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 21-140
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原理
- Anti-ICOS Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-ICOS Antibody Picoband® (ABIN5693002). Tested in ELISA, Flow Cytometry, IHC, ICC applications. This antibody reacts with Human.
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免疫原
- E. coli-derived human ICOS recombinant protein (Position: E21-K140).
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亚型
- IgG
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anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 21-140) antibody
ICOS 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 156-185) antibodyICOS 适用: 人 WB, IHC, FACS, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (Internal Region) antibodyVerified ICOS 适用: 人 IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) antibodyICOS 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 21-200) antibodyICOS 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 1-199) antibodyICOS 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) antibodyICOS 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 21-140) antibodyICOS 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G4 unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) antibodyICOS 适用: 人 IHC, FACS, IP, IHC (fro) 宿主: 小鼠 Monoclonal ISA-3 unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 39-133) antibodyICOS 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL
Immunocytochemistry, 0.5-1 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x106 cells
ELISA, 0.1-0.5 μg/mL
1. Hutloff A, Dittrich AM, Beier KC, Eljaschewitsch B, Kraft R, Anagnostopoulos I, Kroczek RA (Jan 1999). "ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28". Nature. 397(6716): 263-6. 2. Rudd CE, Schneider H (Jul 2003). "Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling". Nature Reviews. Immunology. 3 (7): 544-56. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- ICOS (Inducible T-Cell Co-Stimulator (ICOS))
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别名
- ICOS
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背景
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Synonyms: Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, CD278, ICOS, AILIM
Tissue Specificity: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
Background: Inducible T-cell costimulator is an immune checkpoint protein that in humans is encoded by the ICOS gene. The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
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分子量
- 20 kDa
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基因ID
- 29851
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UniProt
- Q9Y6W8
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途径
- Cancer Immune Checkpoints
抗原
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