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ADA 抗体 (AA 2-238)

Name: ADA 抗体 (AA 2-238)
SKU: ABIN5692790
Availability: OutOfStock

ADA 适用: 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of ADA using anti-ADA antibody . (ADA 抗体 (AA 2-238))

IHC analysis of ADA using anti-ADA antibody . (ADA 抗体 (AA 2-238))

IHC

6 images

产品编号 ABIN5692790

发货至: 中国

Datasheet as PDF

抗原 See all ADA 抗体

ADA (Adenosine Deaminase (ADA))
抗原表位
15

9

8

8

6

4

3

2

2

2

2

1

1

1

1

1

1

1

1
AA 2-238
适用
66

34

18

14

3

3

2

2

2

2

1

1
小鼠, 大鼠
宿主
75

20

1
兔
Compatible Secondaries
克隆类型
77

19
多克隆
标记
52

8

6

6

4

3

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This ADA antibody is un-conjugated
应用范围
85

41

15

14

13

13

13

12

10

5

3

3

2

2

2

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

原理

Anti-ADA Antibody Picoband®

交叉反应（详细）

No cross-reactivity with other proteins.

产品特性

Anti-ADA Antibody Picoband® (ABIN5692790). Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

免疫原

E. coli-derived mouse ADA recombinant protein (Position: A2-H238).

亚型

IgG

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ADA 适用: 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Adenosine Deaminase (ADA) (AA 1-363) antibody
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ADA 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Blackburn MR (2003). "Too much of a good thing: adenosine overload in adenosine-deaminase-deficient mice". Trends in Pharmacological Sciences 24 (2): 66-70. 2. Cristalli G, Costanzi S, Lambertucci C, Lupidi G, Vittori S, Volpini R, Camaioni E (Mar 2001). "Adenosine deaminase: functional implications and different classes of inhibitors". Medicinal Research Reviews 21 (2): 105-128. 3. Wilson DK, Rudolph FB, Quiocho FA (May 1991). "Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations". Science 252(5010): 1278-1284.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.01 mg NaN₃.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
抗原

ADA (Adenosine Deaminase (ADA))

别名

Ada (ADA 产品)

背景

Synonyms: Adenosine deaminase
Tissue Specificity: Detected in brain neurons in the median emninence (at protein level) (PubMed:8783262). Expressed in secondary deciduum (at protein level) (PubMed:9272950). Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues.
Background: Adenosine Deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme involved in purine metabolism. Primarily, ADA in humans is involved in the development and maintenance of the immune system. However, ADA association has also been observed with epithelial cell differentiation, neurotransmission, and gestation maintenance. It has also been proposed that ADA, in addition to adenosine breakdown, stimulates release of excitatory amino acids and is necessary to the coupling of A1 adenosine receptors and heterotrimeric G proteins. Adenosine deaminase deficiency leads to pulmonary fibrosis, suggesting that chronic exposure to high levels of adenosine can exacerbate inflammation responses rather than suppressing them. It has also been recognized that adenosine deaminase protein and activity is upregulated in mouse hearts that overexpress HIF-1 alpha, which in part explains the attenuated levels of adenosine in HIF-1 alpha expressing hearts during ischemic stress.

分子量

45 kDa

基因ID

11486

UniProt

P03958

途径

Regulation of G-Protein Coupled Receptor Protein Signaling, Ribonucleoside Biosynthetic Process