GPX8 抗体 (AA 38-209)
The 兔 多克隆 anti-GPX8 antibody is suitable to detect GPX8 in samples from 人. It has been validated for WB 和 ICC.
产品编号 ABIN5690344
发货至:
中国
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北京 101111
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Quick Overview for GPX8 抗体 (AA 38-209) (ABIN5690344)
抗原
See all GPX8 抗体
GPX8
(Glutathione Peroxidase 8 (GPX8))
适用
人
宿主
兔
克隆类型
多克隆
标记
This GPX8 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunocytochemistry (ICC)
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抗原表位
- AA 38-209
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特异性
- Recognizes human GPx8.
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免疫原
- Recombinant GPx8 (human) (aa 38-209) fused to a GST-tag.
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anti-Glutathione Peroxidase 8 (GPX8) (AA 41-209) antibody
GPX8 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Peroxidase 8 (GPX8) (AA 1-209) antibodyGPX8 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Western Blot: (1:1,000). ICC: (1:200).
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for at least 1 year after receipt when stored at -20°C.
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- GPX8 (Glutathione Peroxidase 8 (GPX8))
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别名
- GPx8
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背景
- GPxs are glutathione peroxidases involved in balancing the H2O2 homeostasis in signaling cascades. GPxs have been known to catalyze the reduction of H2O2 or organic hydroperoxides to water or the corresponding alcohols, respectively, typically using glutathione (GSH) as reductant. GPx8 (probable glutathione peroxidase 8) is a 209-aa, 24 kDa protein with an N-terminal cytosolic tip, a predicted transmembrane segment and a catalytic domain located in the endoplasmic reticulum (ER) lumen. GPx8 is a CysGPxs with low glutathione peroxidase activity. A recent study identified GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease. GPx8 cleavage by NS3-4A occurs at Cys11, removing the cytosolic tip of GPx8 and was observed in different experimental systems as well as in liver biopsies from patients with chronic hepatitis C.
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基因ID
- 493869
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UniProt
- Q8TED1
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途径
- Thyroid Hormone Synthesis
抗原
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