GPX8 抗体 (AA 38-209)
Our Local Distributor
北京 101111
Quick Overview for GPX8 抗体 (AA 38-209) (ABIN2745532)
抗原
See all GPX8 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 38-209
-
原理
- anti-GPx8 (human), pAb (IN103)
-
特异性
- Recognizes human GPx8.
-
产品特性
- Polyclonal Antibody. Recognizes human GPx8. Source: Rabbit. Applications: ICC, WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. GPxs are glutathione peroxidases involved in balancing the H2O2 homeostasis in signaling cascades. GPxs have been known to catalyze the reduction of H2O2 or organic hydroperoxides to water or the corresponding alcohols, respectively, typically using glutathione (GSH) as reductant. GPx8 (probable glutathione peroxidase 8) is a 209-aa, 24 kDa protein with an N-terminal cytosolic tip, a predicted transmembrane segment and a catalytic domain located in the endoplasmic reticulum (ER) lumen. GPx8 is a CysGPxs with low glutathione peroxidase activity. A recent study identified GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease. GPx8 cleavage by NS3-4A occurs at Cys11, removing the cytosolic tip of GPx8 and was observed in different experimental systems as well as in liver biopsies from patients with chronic hepatitis C.
-
免疫原
- Recombinant GPx8 (human) (aa 38-209) fused to a GST-tag.
-
-
anti-Glutathione Peroxidase 8 (GPX8) (AA 41-209) antibody
GPX8 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Peroxidase 8 (GPX8) (AA 1-209) antibodyGPX8 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Glutathione Peroxidase 8 (GPX8) (AA 164-193), (C-Term) antibodyGPX8 适用: 人 WB 宿主: 兔 Polyclonal RB36510 unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
+4°C
-20°C
Stable for at least 1 year after receipt when stored at -20°C.
-
有效期
- 12 months
-
-
- GPX8 (Glutathione Peroxidase 8 (GPX8))
-
别名
- GPx8
-
背景
-
Alternate Names/Synonyms: Probable Glutathione Peroxidase 8, GSHPx-8
Product Description: GPxs are glutathione peroxidases involved in balancing the H2O2 homeostasis in signaling cascades. GPxs have been known to catalyze the reduction of H2O2 or organic hydroperoxides to water or the corresponding alcohols, respectively, typically using glutathione (GSH) as reductant. GPx8 (probable glutathione peroxidase 8) is a 209-aa, 24 kDa protein with an N-terminal cytosolic tip, a predicted transmembrane segment and a catalytic domain located in the endoplasmic reticulum (ER) lumen. GPx8 is a CysGPxs with low glutathione peroxidase activity. A recent study identified GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease. GPx8 cleavage by NS3-4A occurs at Cys11, removing the cytosolic tip of GPx8 and was observed in different experimental systems as well as in liver biopsies from patients with chronic hepatitis C.
-
UniProt
- Q8TED1
-
途径
- Thyroid Hormone Synthesis
抗原
-
