Rubicon 抗体 (AA 240-290)
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- 抗原 See all Rubicon (KIAA0226) 抗体
- Rubicon (KIAA0226) (KIAA0226)
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抗原表位
- AA 240-290
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Rubicon antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- Rubicon antibody is human, mouse and rat reactive. Multiple isoforms of Rubicon are known to exist.
- 纯化方法
- Rubicon antibody is affinity chromatography purified via peptide column.
- 免疫原
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Rubicon antibody was raised against a 16 amino acid peptide near the amino terminus of human Rubicon.
The immunogen is located within amino acids 240 - 290 of Rubicon. - 亚型
- IgG
- Top Product
- Discover our top product KIAA0226 Primary Antibody
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anti-KIAA0226 (KIAA0226) (AA 656-684) antibody
KIAA0226 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB18182 unconjugated
anti-KIAA0226 (KIAA0226) (N-Term) antibody (APC)KIAA0226 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal APC
anti-KIAA0226 (KIAA0226) (N-Term) antibody (Atto 594)KIAA0226 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 594
anti-KIAA0226 (KIAA0226) (N-Term) antibody (Atto 488)KIAA0226 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 488
anti-KIAA0226 (KIAA0226) (N-Term) antibody (Atto 390)KIAA0226 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 390
anti-KIAA0226 (KIAA0226) (AA 1-375) antibodyKIAA0226 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G8 unconjugated
anti-KIAA0226 (KIAA0226) (N-Term) antibodyKIAA0226 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-KIAA0226 (KIAA0226) (N-Term) antibody (HRP)KIAA0226 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal HRP
anti-KIAA0226 (KIAA0226) (N-Term) antibody (FITC)KIAA0226 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal FITC
anti-KIAA0226 (KIAA0226) (N-Term) antibody (Biotin)KIAA0226 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal Biotin
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- 应用备注
- Rubicon body can be used for detection of Rubicon by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rubicon antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Rubicon antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- 抗原
- Rubicon (KIAA0226) (KIAA0226)
- 别名
- Rubicon (KIAA0226 产品)
- 别名
- RUBICON antibody, 5330403K09 antibody, Kiaa0226 antibody, Rubicon antibody, mKIAA0226 antibody, RUN and cysteine rich domain containing beclin 1 interacting protein antibody, KIAA0226 antibody, RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein antibody, RUBCN antibody, KIAA0226 antibody, Rubcn antibody
- 背景
- Two Beclin-1-interacting proteins, the run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) and ATG14L, reciprocally regulate autophagy at different stages. Knockdown of Rubicon caused enhancement of autophagy while that of ATG14L caused a defect in autophagosome formation (1). Rubicon functions as part of a Beclin-1-PIK3C3-containing autophagy complex and is also an essential, positive regulator of the NAPDH oxidase complex (2). Upon microbial infection or TLR2 activation, Rubicon interacts with the CYBA subunit of the NAPDH oxidase complex, leading to a burst of reactive oxygen species and inflammatory cytokines (2).
- 分子量
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Predicted: 90, 101, 109 kDa
Observed: 91, 99 kDa - 基因ID
- 9711
- NCBI登录号
- XP_005269431
- UniProt
- Q92622
- 途径
- Autophagy
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