LIN28B 抗体 (AA 242-246)
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北京 101111
Quick Overview for LIN28B 抗体 (AA 242-246) (ABIN5689573)
抗原
See all LIN28B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 242-246
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特异性
- This antibody detects endogenous levels of total LIN28B protein.
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纯化方法
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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免疫原
- LIN28B antibody was raised against a peptide sequence around aa.242~246 ( P-S-V-Q-K) derived from Human LIN28B.
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anti-Lin-28 Homolog B (LIN28B) (AA 95-128) antibody
LIN28B 适用: 人 WB, ELISA, FACS, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) (AA 1-30) antibodyLIN28B 适用: 人 WB, ELISA, FACS, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) (AA 166-250) antibodyLIN28B 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) antibodyLIN28B 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) (AA 218-250) antibodyLIN28B 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) (AA 95-128) antibodyLIN28B 适用: 人 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) antibodyLIN28B 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) (AA 200-250) antibodyLIN28B 适用: 人, 猴 IHC, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) (N-Term) antibodyLIN28B 适用: 人 WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) (Center) antibodyLIN28B 适用: 人 WB, FACS, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western Blot: 1:500~1:1000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store antibody at -20°C for up to one year.
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- LIN28B (Lin-28 Homolog B (LIN28B))
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别名
- LIN28B
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背景
- Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.
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分子量
- 21 32 kDa
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基因ID
- 389421
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NCBI登录号
- NP_001004317
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UniProt
- Q6ZN17
抗原
-
