Cortactin 抗体 (AA 419-423)
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Quick Overview for Cortactin 抗体 (AA 419-423) (ABIN5689260)
抗原
See all Cortactin (CTTN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 419-423
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特异性
- This antibody detects endogenous level of total Cortactin protein.
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纯化方法
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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免疫原
- Cortactin (Ab-421) antibody was raised against a peptide sequence around aa.419~423 (P-I-Y-E-D) derived from Human CORTACTIN.
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应用备注
- Immunohistochemistry: 1:50~1:100
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store antibody at -20°C for up to one year.
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- Cortactin (CTTN)
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别名
- Cortactin
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背景
- Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.
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分子量
- 85 kDa
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基因ID
- 2017
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NCBI登录号
- NP_005222
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UniProt
- Q14247
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途径
- MAPK Pathway
抗原
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