Glutamate Receptor 1 抗体 (pSer845)
Quick Overview for Glutamate Receptor 1 抗体 (pSer845) (ABIN5688909)
抗原
See all Glutamate Receptor 1 (GLUR1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer845
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特异性
- GluR1 antibody is specific for GluR1 phosphorylated at Ser845.
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纯化方法
- Affinity Purified
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免疫原
- GluR1 (Ser845) polyclonal antibody was raised against a synthetic phosphopeptide corresponding to amino acids residues surrounding the phospho-Ser845 of rat GluR1.
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anti-Glutamate Receptor 1 (GLUR1) (AA 19-300) antibody
GLUR1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor 1 (GLUR1) (pSer845) antibodyGLUR1 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor 1 (GLUR1) (AA 19-360) antibodyGLUR1 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor 1 (GLUR1) antibodyMicroarray verified GLUR1 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB177574 unconjugated
anti-Glutamate Receptor 1 (GLUR1) (C-Term) antibodyGLUR1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor 1 (GLUR1) (pSer831) antibodyGLUR1 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibodyGLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 unconjugated
anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (HRP)GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 HRP
anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (FITC)GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 FITC
anti-Glutamate Receptor 1 (GLUR1) (AA 1-389) antibody (Biotin)GLUR1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S355-1 Biotin
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应用备注
- Immunolabeling of the GluR1 protein in western blots of rat brain is blocked by the Ser845 phosphopeptide used as antigen but not by the corresponding non-phosphopeptide. The antibody is purified by sequential chromatography on phospho- and non-phosphopeptide affinity columns. Antibody dilutions and tissue load should be based on tissue type and expected phosphorylation state. Initial recommended range of dilutions: 1:500 to 1:2000. Applications include Immunofluorescence (IF), Immunohistochemistry (IHC) and Western Blots (WB). Immunohistochemistry (IHC) has not yet been determined. Human, mouse and rat have 100 % amino acid sequence identity with the antigen used to raise the antibody. When internally tested under ideal conditions the working dilutions were 1:1000 for IF, IHC and WB.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 100 μLin 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
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储存条件
- -20 °C
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储存方法
- For long term storage -80°C is recommended, but shorter term storage at -20°C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stable for one year.
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- Glutamate Receptor 1 (GLUR1)
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别名
- GluR1
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背景
- The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of 4 distinct subunits (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR1 subunit is widely expressed throughout the nervous system. GluR1 is also potentiated by phosphorylation at Ser845. In addition, phosphorylation of this site has been linked to synaptic plasticity as well and learning and memory.
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分子量
- 100 kDa
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基因ID
- 50592
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UniProt
- P19490
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途径
- PI3K-Akt Signaling
抗原
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