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Choline Acetyltransferase 抗体

CHAT 适用: 人, 小鼠, 大鼠, 小鸡, 山羊 WB, IHC 宿主: 山羊 Polyclonal unconjugated
产品编号 ABIN5687549
发货至: 中国
  • 抗原 See all Choline Acetyltransferase (CHAT) 抗体
    Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))
    适用
    • 66
    • 42
    • 38
    • 17
    • 5
    • 2
    • 2
    • 1
    人, 小鼠, 大鼠, 小鸡, 山羊
    宿主
    • 63
    • 6
    • 4
    • 3
    • 2
    山羊
    克隆类型
    • 65
    • 13
    多克隆
    标记
    • 42
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Choline Acetyltransferase antibody is un-conjugated
    应用范围
    • 42
    • 23
    • 22
    • 22
    • 14
    • 14
    • 13
    • 13
    • 7
    • 6
    • 4
    • 3
    • 1
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    Western Blotting (WB), Immunohistochemistry (IHC)
    特异性
    Specific for the ~ 70k choline acetyltransferase protein
    纯化方法
    Affinity Purified
    免疫原
    Native choline acetyltransferase purified from human placenta.
    Top Product
    Discover our top product CHAT Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
    储存条件
    -20 °C
    储存方法
    Choline Acetyltransferase antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
  • Gonzales, Pare, Wichmann, Smith: "GABAergic inputs from direct and indirect striatal projection neurons onto cholinergic interneurons in the primate putamen." in: The Journal of comparative neurology, Vol. 521, Issue 11, pp. 2502-22, (2014) (PubMed).

  • 抗原
    Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))
    别名
    Choline Acetyltransferase (CHAT 产品)
    别名
    CHOACTASE antibody, CMS1A antibody, CMS1A2 antibody, ChoAcTase antibody, B230380D24Rik antibody, choline O-acetyltransferase antibody, choline O-acetyltransferase a antibody, choline acetyltransferase antibody, carnitine O-acetyltransferase antibody, CHAT antibody, chata antibody, Chat antibody, PGTG_00551 antibody, LOC100533322 antibody
    背景
    Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999).
    分子量
    70 kDa
    基因ID
    1103
    UniProt
    P28329
    途径
    Skeletal Muscle Fiber Development
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