Specific for the ~68k Neurofilament L protein in Western blots and works well on frozen sections, cells in tissue culture and on mildly formalin fixed histological sections.
纯化方法
Total IgY fraction
免疫原
Preparation of bovine spinal cord intermediate filaments
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
状态
Liquid
储存条件
-20 °C
储存方法
Neurofilament NF-L antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
抗原
NEFL
(Neurofilament, Light Polypeptide (NEFL))
别名
Neurofilament NF-L
背景
Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at about 68 kDa. Antibodies to NF-L are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. Mutations in the protein coding region of the human NF-L gene cause some forms of Charcot-Marie-Tooth disease.