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CD80 抗体

This anti-CD80 antibody is a 仓鼠 单克隆 antibody detecting CD80 in FACS, IP, IHC (fro) 和 Func. Suitable for 小鼠 和 犬. This Primary Antibody has been cited in 8+ publications.
产品编号 ABIN567985
发货至: 中国

Quick Overview for CD80 抗体 (ABIN567985)

抗原

See all CD80 抗体
CD80

适用

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小鼠, 犬

宿主

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仓鼠

克隆类型

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单克隆

标记

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This CD80 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

克隆位点

16-10A1
  • 特异性

    This Hamster antibody reacts with CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.

    交叉反应 (详细)

    Species reactivity (tested):Mouse, Canine (Dog).

    纯化方法

    Protein-A affinity chromatography

    免疫原

    CD80-transfected CHO cell line

    亚型

    IgG2
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH ~7.4 with 15 mM Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Mukherjee, Ahmed, Malu, Nandi: "Modulation of cell cycle progression by CTLA4-CD80/CD86 interactions on CD4+ T cells depends on strength of the CD3 signal: critical role for IL-2." in: Journal of leukocyte biology, Vol. 80, Issue 1, pp. 66-74, (2006) (PubMed).

    Odobasic, Kitching, Semple, Timoshanko, Tipping, Holdsworth: "Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis." in: Journal of the American Society of Nephrology : JASN, Vol. 16, Issue 7, pp. 2012-22, (2005) (PubMed).

    Huet, Bagot, Loyaux, Capdevielle, Conraux, Ferrara, Bensussan, Marie-Cardine: "SC5 mAb represents a unique tool for the detection of extracellular vimentin as a specific marker of Sezary cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 1, pp. 652-9, (2005) (PubMed).

    Paust, Lu, McCarty, Cantor: "Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 28, pp. 10398-403, (2004) (PubMed).

    Reiser, von Gersdorff, Loos, Oh, Asanuma, Giardino, Rastaldi, Calvaresi, Watanabe, Schwarz, Faul, Kretzler, Davidson, Sugimoto, Kalluri, Sharpe, Kreidberg, Mundel: "Induction of B7-1 in podocytes is associated with nephrotic syndrome." in: The Journal of clinical investigation, Vol. 113, Issue 10, pp. 1390-7, (2004) (PubMed).

    Quah, Ni, ONeill: "In vitro hematopoiesis produces a distinct class of immature dendritic cells from spleen progenitors with limited T cell stimulation capacity." in: International immunology, Vol. 16, Issue 4, pp. 567-77, (2004) (PubMed).

    Mencacci, Montagnoli, Bacci, Cenci, Pitzurra, Spreca, Kopf, Sharpe, Romani: "CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 6, pp. 3180-90, (2002) (PubMed).

    Horspool, Perrin, Woodcock, Cox, King, June, Harlan, St Louis, Lee: "Nucleic acid vaccine-induced immune responses require CD28 costimulation and are regulated by CTLA4." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 6, pp. 2706-14, (1998) (PubMed).

  • 抗原

    CD80

    别名

    CD80

    背景

    CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 Molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet, there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.Synonyms: Activation B7-1 antigen, B7-1, B7.1, BB1, CD28LG, CD28LG1, CTLA-4 counter-receptor B7.1, LAB7, T-lymphocyte activation antigen CD80

    基因ID

    12519

    NCBI登录号

    NP_033985

    UniProt

    Q00609

    途径

    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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