KIT 抗体 (AA 451-550)
Quick Overview for KIT 抗体 (AA 451-550) (ABIN5675784)
抗原
See all KIT 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 451-550
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交叉反应
- 人, 小鼠
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预测反应
- Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human KIT
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亚型
- IgG
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anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 350-440) antibody
KIT 适用: 人, 小鼠, 大鼠 FACS, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 321-520) antibodyKIT 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 343-527) antibodyKIT 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mast/stem Cell Growth Factor Receptor (KIT) (Internal Region) antibodyVerified KIT 适用: 人 WB, FACS, ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibodyKIT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr703) antibodyKIT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 546-976) antibodyKIT 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2E3 unconjugated
anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 25-295) antibodyKIT 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mast/stem Cell Growth Factor Receptor (KIT) antibody (FITC)KIT 适用: 人, Cow, Non-Human Primate FACS 宿主: 小鼠 Monoclonal 104D2 FITC
anti-Mast/stem Cell Growth Factor Receptor (KIT) antibodyKIT 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 1C5 unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- KIT (Mast/stem Cell Growth Factor Receptor (KIT))
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别名
- KIT
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背景
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Synonyms: Mast/stem cell growth factor receptor Kit, KIT, SCFR, PBT, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, CD_antigen: CD117
Background: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
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基因ID
- 17210
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UniProt
- P10721
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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