NONO 抗体 (AA 21-120)
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- 抗原 See all NONO 抗体
- NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
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抗原表位
- AA 21-120
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适用
- 人, 山羊
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NONO antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 山羊, 人
- 预测反应
- Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human NMT55
- 亚型
- IgG
- Top Product
- Discover our top product NONO Primary Antibody
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anti-Non-POU Domain Containing, Octamer-Binding (NONO) (AA 184-385) antibody
NONO 适用: 人, 小鼠, 犬, 猴 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-Non-POU Domain Containing, Octamer-Binding (NONO) (AA 184-385) antibodyNONO 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2E7 unconjugated
anti-Non-POU Domain Containing, Octamer-Binding (NONO) (AA 1-300) antibodyNONO 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Non-POU Domain Containing, Octamer-Binding (NONO) antibodyNONO 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Non-POU Domain Containing, Octamer-Binding (NONO) (C-Term) antibodyNONO 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠, 兔 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Non-POU Domain Containing, Octamer-Binding (NONO) antibodyNONO 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Monoclonal 8C11 unconjugated Recombinant Antibody
anti-Non-POU Domain Containing, Octamer-Binding (NONO) (N-Term) antibodyNONO 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Non-POU Domain Containing, Octamer-Binding (NONO) (C-Term) antibodyNONO 适用: 人, 犬, 猴, 马, Cow, 豚鼠, 兔, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Non-POU Domain Containing, Octamer-Binding (NONO) (AA 1-35), (N-Term) antibodyNONO 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Non-POU Domain Containing, Octamer-Binding (NONO) (N-Term) antibodyNONO 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
- 别名
- NMT55 (NONO 产品)
- 别名
- NMT55 antibody, NRB54 antibody, P54 antibody, P54NRB antibody, nmt55 antibody, nrb54 antibody, p54nrb antibody, xp54nrb antibody, AA407051 antibody, AV149256 antibody, nonA antibody, non-POU domain containing octamer binding antibody, non-POU domain containing, octamer-binding antibody, non-POU domain containing, octamer binding L homeolog antibody, non-POU-domain-containing, octamer binding protein antibody, NONO antibody, Nono antibody, nono.L antibody
- 背景
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Synonyms: Non-POU domain-containing octamer-binding protein, NONO, 54 kDa nuclear RNA- and DNA-binding protein, 55 kDa nuclear protein, DNA-binding p52/p100 complex, 52 kDa subunit, NMT55, p54(nrb), p54nrb, NRB54
Background: DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site (By similarity). Involved in pre-mRNA splicing, probably as an heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. Nono is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription.
- 基因ID
- 4841
- UniProt
- Q15233
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