MCU 抗体 (C-Term)
Quick Overview for MCU 抗体 (C-Term) (ABIN5673971)
抗原
See all MCU 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- YPEARDRQYL LFFHKGAKKS RFDLEKYNQL KDAIAQAEMD LKRLRDPLQV
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纯化方法
- Affinity purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of mouse CCDC109A
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anti-Mitochondrial Calcium Uniporter (MCU) (AA 1-351) antibody
MCU 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial Calcium Uniporter (MCU) (AA 155-233) antibodyMCU 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial Calcium Uniporter (MCU) (Internal Region) antibodyMCU 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial Calcium Uniporter (MCU) (AA 191-206), (Mitochondrial Matrix) antibodyMCU 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- MCU (Mitochondrial Calcium Uniporter (MCU))
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别名
- CCDC109A
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背景
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Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (By similarity). Activity is regulated by MICU1 and MICU2 (By similarity). At low Ca2+ levels MCU activity is down-regulated by MICU1 and MICU2, at higher Ca2+ levels MICU1 increases MCU activity (By similarity). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (By similarity). Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (By similarity). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. Participates in mitochondrial permeability transition during ischemia-reperfusion injury (PubMed:26119731). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (By similarity). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults. Regulates synaptic vesicle endocytosis kinetics in central nerve terminal. Involved in antigen processing and presentation.
Alias Symbols: Gm64, AV064928, C10orf42, Ccdc109a, 2010012O16Rik, D130073L02Rik
Protein Size: 201 -
基因ID
- 215999
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NCBI登录号
- NM_001033259, NP_001028431
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途径
- Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis
抗原
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