Nischarin 抗体 (C-Term)
Quick Overview for Nischarin 抗体 (C-Term) (ABIN5672022)
抗原
See all Nischarin (NISCH) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- LLDEDCVHYP LPEFAKEPPQ RDRYRLDDGR RVRDLDRVLM GYQTYPQALT
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纯化方法
- Affinity purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human NISCH
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anti-Nischarin (NISCH) (AA 500-700) antibody
NISCH 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Nischarin (NISCH) (AA 1246-1345) antibodyNISCH 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B8 unconjugated
anti-Nischarin (NISCH) (AA 1246-1346) antibodyNISCH 适用: 人 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nischarin (NISCH) (AA 1335-1435) antibodyNISCH 适用: 小鼠 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nischarin (NISCH) (AA 5-38) antibodyNISCH 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB55910 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Nischarin (NISCH)
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别名
- NISCH
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背景
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This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis, possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor.
Alias Symbols: I-1, IR1, IRAS, hIRAS
Protein Size: 993 -
基因ID
- 11188
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NCBI登录号
- NM_001276293, NP_001263222
抗原
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