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CERS6 抗体 (AA 62-131)

This anti-CERS6 antibody is a 小鼠 单克隆 antibody detecting CERS6 in ELISA, WB 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 7+ publications.
产品编号 ABIN566979
发货至: 中国

Quick Overview for CERS6 抗体 (AA 62-131) (ABIN566979)

抗原

See all CERS6 抗体
CERS6 (Ceramide Synthase 6 (CERS6))

适用

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宿主

  • 29
  • 3
小鼠

克隆类型

  • 30
  • 2
单克隆

标记

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This CERS6 antibody is un-conjugated

应用范围

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  • 5
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ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

5H7
  • 抗原表位

    • 8
    • 7
    • 6
    • 2
    • 2
    • 1
    AA 62-131

    原理

    Mouse monoclonal antibody raised against a partial recombinant LASS6.

    序列

    PCAIALNIQA NGPQIAPPNA ILEKVFTAIT KHPDEKRLEG LSKQLDWDVR SIQRWFRQRR NQEKPSTLTR

    交叉反应

    产品特性

    Antibody Reactive Against Recombinant Protein.

    免疫原

    LASS6 (NP_982288, 62 a.a. ~ 131 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

    亚型

    IgG2a
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 缓冲液

    In 1x PBS, pH 7.4

    注意事项

    Aliquot to avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Suzuki, Cao, Kato, Komizu, Mizutani, Tanaka, Arima, Tai, Yanagisawa, Togawa, Shiraishi, Usami, Taniguchi, Fukui, Yokoi, Wakahara, Hasegawa, Mizutani, Igarashi, Inokuchi, Iwaki, Fujii, Satou et al.: "Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells. ..." in: The Journal of clinical investigation, Vol. 126, Issue 1, pp. 254-65, (2016) (PubMed).

    Gerl, Bittl, Kirchner, Sachsenheimer, Brunner, Lüchtenborg, Özbalci, Wiedemann, Wegehingel, Nickel, Haberkant, Schultz, Krüger, Brügger: "Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions." in: PLoS ONE, Vol. 11, Issue 4, pp. e0153009, (2016) (PubMed).

    Jensen, Calvert, Volpert, Kouri, Hurley, Luciano, Wu, Chalastanis, Futerman, Stegh: "Bcl2L13 is a ceramide synthase inhibitor in glioblastoma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 15, pp. 5682-7, (2014) (PubMed).

    Laviad, Kelly, Merrill, Futerman: "Modulation of ceramide synthase activity via dimerization." in: The Journal of biological chemistry, Vol. 287, Issue 25, pp. 21025-33, (2012) (PubMed).

    Yamane, Miyazawa, Moriya, Abe, Yamane et al.: "D,L-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (DL-PDMP) increases endoplasmic reticulum stress, autophagy and apoptosis accompanying ceramide accumulation via ceramide synthase 5 protein ..." in: Biochimie, Vol. 93, Issue 9, pp. 1446-59, (2011) (PubMed).

    Mesicek, Lee, Feldman, Jiang, Skobeleva, Berdyshev, Haimovitz-Friedman, Fuks, Kolesnick: "Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells." in: Cellular signalling, Vol. 22, Issue 9, pp. 1300-7, (2010) (PubMed).

    in: (PubMed).

  • 抗原

    CERS6 (Ceramide Synthase 6 (CERS6))

    别名

    LASS6

    背景

    Full Gene Name: LAG1 homolog, ceramide synthase 6
    Synonyms: CerS6,MGC129949,MGC129950

    基因ID

    253782

    NCBI登录号

    NM_203463
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