Recombinant ErbB2/Her2 (Trastuzumab Biosimilar) 抗体
(1 reference)Quick Overview for Recombinant ErbB2/Her2 (Trastuzumab Biosimilar) 抗体 (ABIN5668226)
抗原
抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)], Human IgG1, kappa
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特异性
- Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30 % of invasive breast cancers and 70 % of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder.
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产品特性
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Original Species of Ab: Human
Original Format of Ab: IgG1
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纯化方法
- Protein A affinity purified
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纯度
- > 98 % as determined by SDS-PAGE
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内毒素水平
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
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免疫原
- A431 cells (human epidermoid carcinoma) (over)expressing EGFR.
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亚型
- IgG1 kappa
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anti-ErbB2/Her2 (Trastuzumab Biosimilar) antibody
Research Grade 适用: 人 FACS, ELISA 宿主: Humanized Monoclonal unconjugated Recombinant Antibody
anti-ErbB2/Her2 (Trastuzumab Biosimilar) antibody适用: 人 FACS, ELISA, IHC 宿主: 兔 Chimeric 4D5-8 unconjugated Recombinant Antibody
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应用备注
- This antibody binds to erbB-2/Her-2/neu has therapeutic indications particularly in the treatment of breast cancer (c.f. Herceptin). It can also be used to detect HER-2 by flow cytometry or IHC (Glazyrin 2007).
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说明
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NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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: "Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer." in: Journal of translational medicine, Vol. 17, Issue 1, pp. 201, (2020) (PubMed).
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: "Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer." in: Journal of translational medicine, Vol. 17, Issue 1, pp. 201, (2020) (PubMed).
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- ErbB2/Her2 (Trastuzumab Biosimilar)
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物质类
- Biosimilar
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背景
- CD340, Metastatic lymph node gene 19 protein (MLN 19), Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, p185HER2, EGFR
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UniProt
- P04626
抗原
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