APC2 抗体 (AA 51-90)
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Quick Overview for APC2 抗体 (AA 51-90) (ABIN5647467)
抗原
See all APC2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 51-90
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纯化方法
- Antigen affinity purified
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免疫原
- Amino acids 51-90 (KHLQGKLEQEARVLVSSGQTEVLEQLKALQMDITSLYNLK) from the human protein were used as the immunogen for the APC2 antibody.
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亚型
- IgG
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应用备注
- Western blot: 0.5-1 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the APC2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))
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别名
- APC2
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背景
- APC2, also called APCL or Adenomatous polyposis coli protein-like, is a deduced 2,303-amino acid protein that contains an N-terminal coiled-coil domain, followed by an armadillo domain and five 20-amino acid repeats. The human APC2 gene is mapped to chromosome 19p13.3. It is found that the 20-amino acid repeat domain of APCL could bind beta-catenin (CTNNB1) and deplete the intracellular beta-catenin pool. A reporter gene assay revealed that APCL could regulate interaction of beta-catenin with T cell-specific transcription factors (TCF7), although less efficiently than APC.
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UniProt
- O95996
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途径
- WNT signaling
抗原
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