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SIX3 抗体 (AA 1-32)

SIX3 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5647434
发货至: 中国
  • 抗原 See all SIX3 抗体
    SIX3 (Sine Oculis-Related Homeobox 3 (SIX3))
    抗原表位
    • 15
    • 9
    • 8
    • 8
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-32
    适用
    • 49
    • 18
    • 15
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    小鼠, 大鼠
    宿主
    • 48
    • 3
    • 1
    • 1
    克隆类型
    • 51
    • 2
    多克隆
    标记
    • 22
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This SIX3 antibody is un-conjugated
    应用范围
    • 45
    • 22
    • 13
    • 13
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    交叉反应 (详细)
    Expected species reactivity: Human
    纯化方法
    Antigen affinity purified
    免疫原
    Amino acids 1-32 (MVFRSPLDLYSSHFLLPNFADSHHRSILLASS) were used as the immunogen for the Six3 antibody.
    亚型
    IgG
    Top Product
    Discover our top product SIX3 Primary Antibody
  • 应用备注
    Optimal dilution of the Six3 antibody should be determined by the researcher.\. Western Blot: 0.5-1 μg/mL
    限制
    仅限研究用
  • 缓冲液
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    储存条件
    -20 °C
    储存方法
    After reconstitution, the Six3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原
    SIX3 (Sine Oculis-Related Homeobox 3 (SIX3))
    别名
    Six3 (SIX3 产品)
    别名
    HPE2 antibody, SIX3 antibody, cb347 antibody, six3.2 antibody, six6 antibody, E130112M24Rik antibody, Six3a antibody, Six3alpha antibody, Six3b antibody, Six3beta antibody, six3 antibody, six3.1 antibody, wu:fc10a08 antibody, SIX homeobox 3 antibody, SIX homeobox 3b antibody, sine oculis-related homeobox 3 antibody, SIX homeobox 3a antibody, sine oculis homeobox homolog 3 antibody, SIX3 antibody, six3b antibody, Six3 antibody, six3a antibody, six3 antibody
    背景
    Homeobox protein SIX3 is a protein that in humans is encoded by the SIX3 gene. This gene encodes a member of the sine oculishomeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in SIX3 are the cause of a severe brain malformation, called holoprosencephaly type 2 (HPE2). In HPE2, the brain fails to separate into two hemispheres during early embryonic development, leading to eye and brain malformations, which result in serious facial abnormalities. A mutant zebrafish knockout model has been developed, in which the anterior part of the head was missing due to the atypical increase of Wnt1 activity. When injected with SIX3, these zebrafish embryos were able to successfully develop a normal forebrain. When SIX3 was turned off in mice, resulting in a lack of retina formation due to excessive expression of Wnt8b in the region where the forebrain normally develops. Both of these studies demonstrate the importance of SIX3 activity in brain and eye development.
    UniProt
    O95343
    途径
    Protein targeting to Nucleus
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