SIX3 抗体 (AA 1-32)
Quick Overview for SIX3 抗体 (AA 1-32) (ABIN5647434)
抗原
See all SIX3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-32
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交叉反应 （详细）
- Expected species reactivity: Human
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纯化方法
- Antigen affinity purified
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免疫原
- Amino acids 1-32 (MVFRSPLDLYSSHFLLPNFADSHHRSILLASS) were used as the immunogen for the Six3 antibody.
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亚型
- IgG
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anti-Sine Oculis-Related Homeobox 3 (SIX3) (AA 273-332) antibody
SIX3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4H6 unconjugated
anti-Sine Oculis-Related Homeobox 3 (SIX3) (Internal Region) antibodySIX3 适用: 小鼠 WB, ELISA, IHC, IF, FM, DB 宿主: 豚鼠 Polyclonal unconjugated
anti-Sine Oculis-Related Homeobox 3 (SIX3) (AA 273-332) antibodySIX3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D12 unconjugated
anti-Sine Oculis-Related Homeobox 3 (SIX3) (Internal Region) antibodySIX3 适用: 小鼠 WB, ELISA, IHC, IF, FM, DB 宿主: 豚鼠 Polyclonal unconjugated
anti-Sine Oculis-Related Homeobox 3 (SIX3) (C-Term) antibodySIX3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sine Oculis-Related Homeobox 3 (SIX3) (Internal Region) antibodySIX3 适用: 小鼠 WB, ELISA, IHC, FM 宿主: 兔 Polyclonal unconjugated
anti-Sine Oculis-Related Homeobox 3 (SIX3) (Internal Region) antibodySIX3 适用: 小鼠 WB, ELISA, IHC, FM 宿主: 兔 Polyclonal unconjugated
anti-Sine Oculis-Related Homeobox 3 (SIX3) (AA 1-332) antibodySIX3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Sine Oculis-Related Homeobox 3 (SIX3) (C-Term) antibodySIX3 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Sine Oculis-Related Homeobox 3 (SIX3) (N-Term) antibodySIX3 适用: 人, 小鼠, 大鼠, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Six3 antibody should be determined by the researcher.\. Western Blot: 0.5-1 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the Six3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- SIX3 (Sine Oculis-Related Homeobox 3 (SIX3))
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别名
- Six3
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背景
- Homeobox protein SIX3 is a protein that in humans is encoded by the SIX3 gene. This gene encodes a member of the sine oculishomeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in SIX3 are the cause of a severe brain malformation, called holoprosencephaly type 2 (HPE2). In HPE2, the brain fails to separate into two hemispheres during early embryonic development, leading to eye and brain malformations, which result in serious facial abnormalities. A mutant zebrafish knockout model has been developed, in which the anterior part of the head was missing due to the atypical increase of Wnt1 activity. When injected with SIX3, these zebrafish embryos were able to successfully develop a normal forebrain. When SIX3 was turned off in mice, resulting in a lack of retina formation due to excessive expression of Wnt8b in the region where the forebrain normally develops. Both of these studies demonstrate the importance of SIX3 activity in brain and eye development.
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UniProt
- O95343
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途径
- Protein targeting to Nucleus
抗原
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