Separase 抗体 (AA 586-701)
(7 references)Quick Overview for Separase 抗体 (AA 586-701) (ABIN564183)
抗原
See all Separase (ESPL1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 586-701
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原理
- Mouse monoclonal antibody raised against a partial recombinant ESPL1.
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序列
- REELQAYKAV RADTGQERFN IICDLLELSP EETPAGAWAR ATHLVELAQV LCYHDFTQQT NCSALDAIRE ALQLLDSVRP EAQARDQLLD DKAQALLWLY ICTLEAKIQE GIERDR
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交叉反应
- 人
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产品特性
- Antibody Reactive Against Recombinant Protein.
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免疫原
- ESPL1 (NP_036423, 586 a.a. ~ 701 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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亚型
- IgG2a
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anti-Extra Spindle Poles Like 1 (ESPL1) (Tyr489) antibody
ESPL1 适用: 人, 小鼠 ELISA, IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) (pSer1126) antibodyESPL1 适用: 人 IHC (p), DB 宿主: 兔 Polyclonal RB7943 unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) (AA 767-816) antibodyESPL1 适用: 人, 小鼠 ELISA, IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) (pSer801) antibodyESPL1 适用: 人 IHC, WB, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) (pSer801) antibodyESPL1 适用: 人 ELISA, IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) (AA 1292-1495) antibodyESPL1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) antibodyESPL1 适用: 小鼠 WB 宿主: 山羊 Polyclonal unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) (pSer1126) antibodyESPL1 适用: 人 IF 宿主: 兔 Polyclonal unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) (pSer801) antibodyESPL1 适用: 人, 小鼠 ELISA, IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) (AA 1220-1500) antibodyESPL1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- In 1x PBS, pH 7.4
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注意事项
- Aliquot to avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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: "MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas." in: Oncogene, Vol. 33, Issue 48, pp. 5511-22, (2014) (PubMed).
: "Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme." in: Journal of neuro-oncology, Vol. 119, Issue 1, pp. 27-35, (2014) (PubMed).
: "Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy." in: Journal of biomolecular screening, Vol. 19, Issue 6, pp. 878-889, (2014) (PubMed).
: "Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice." in: PLoS ONE, Vol. 6, Issue 7, pp. e22167, (2011) (PubMed).
: "Calpain-1 cleaves Rad21 to promote sister chromatid separation." in: Molecular and cellular biology, Vol. 31, Issue 21, pp. 4335-47, (2011) (PubMed).
: "Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 8, pp. 2703-10, (2009) (PubMed).
: "Overexpression of Separase induces aneuploidy and mammary tumorigenesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 35, pp. 13033-8, (2008) (PubMed).
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: "MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas." in: Oncogene, Vol. 33, Issue 48, pp. 5511-22, (2014) (PubMed).
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- Separase (ESPL1) (Extra Spindle Poles Like 1 (ESPL1))
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别名
- ESPL1
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背景
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Full Gene Name: extra spindle pole bodies homolog 1 (S. cerevisiae)
Synonyms: ESP1,FLJ46492,KIAA0165,SEPARASE,SEPARIN -
基因ID
- 9700
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NCBI登录号
- NM_012291
抗原
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