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NOTCH3 抗体 (AA 47-156)

This anti-NOTCH3 antibody is a 小鼠 单克隆 antibody detecting NOTCH3 in WB 和 ELISA. Suitable for 人. This Primary Antibody has been cited in 7+ publications.
产品编号 ABIN562028
发货至: 中国

Quick Overview for NOTCH3 抗体 (AA 47-156) (ABIN562028)

抗原

See all NOTCH3 抗体
NOTCH3 (Notch 3 (NOTCH3))

适用

  • 56
  • 19
  • 11
  • 1

宿主

  • 43
  • 15
  • 3
  • 1
  • 1
小鼠

克隆类型

  • 47
  • 17
单克隆

标记

  • 33
  • 4
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
This NOTCH3 antibody is un-conjugated

应用范围

  • 26
  • 25
  • 23
  • 8
  • 7
  • 5
  • 5
  • 3
  • 2
  • 1
Western Blotting (WB), ELISA

克隆位点

1G5
  • 抗原表位

    • 13
    • 11
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 47-156

    原理

    Mouse monoclonal antibody raised against a partial recombinant NOTCH3.

    序列

    SPCANGGRCT QLPSREAACL CPPGWVGERC QLEDPCHSGP CAGRGVCQSS VVAGTARFSC RCPRGFRGPD CSLPDPCLSS PCAHGARCSV GPDGRFLCSC PPGYQGRSCR

    交叉反应

    产品特性

    Antibody Reactive Against Recombinant Protein.

    免疫原

    NOTCH3 (NP_000426, 47 a.a. ~ 156 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

    亚型

    IgG2a
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 缓冲液

    In 1x PBS, pH 7.4

    注意事项

    Aliquot to avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Meng, Zhang, Lee, Wang: "Von Willebrand factor inhibits mature smooth muscle gene expression through impairment of Notch signaling." in: PLoS ONE, Vol. 8, Issue 9, pp. e75808, (2013) (PubMed).

    Watanabe-Hosomi, Watanabe, Tanaka, Nakagawa, Mizuno: "Transendocytosis is impaired in CADASIL-mutant NOTCH3." in: Experimental neurology, Vol. 233, Issue 1, pp. 303-11, (2012) (PubMed).

    Tada, Itoh, Ishii-Watabe, Suzuki, Kawasaki: "Functional analysis of the Notch ligand Jagged1 missense mutant proteins underlying Alagille syndrome." in: The FEBS journal, Vol. 279, Issue 12, pp. 2096-107, (2012) (PubMed).

    Dong, Blaivas, Wang: "Bidirectional encroachment of collagen into the tunica media in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy." in: Brain research, Vol. 1456, pp. 64-71, (2012) (PubMed).

    Lee, Meng, Elmadhoun, Blaivas, Wang: "Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy affecting an African American man: identification of a novel 15-base pair NOTCH3 duplication." in: Archives of neurology, Vol. 68, Issue 12, pp. 1584-6, (2011) (PubMed).

    Meng, Zhang, Hankenson, Wang: "Thrombospondin 2 potentiates notch3/jagged1 signaling." in: The Journal of biological chemistry, Vol. 284, Issue 12, pp. 7866-74, (2009) (PubMed).

    Park, Shih, Wang: "Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer." in: Cancer research, Vol. 68, Issue 21, pp. 8852-60, (2008) (PubMed).

  • 抗原

    NOTCH3 (Notch 3 (NOTCH3))

    别名

    NOTCH3

    背景

    Full Gene Name: Notch homolog 3 (Drosophila)
    Synonyms: CADASIL,CASIL

    基因ID

    4854

    NCBI登录号

    NM_000435

    途径

    Notch Signaling
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