APC2 抗体 (AA 2041-2181)
Quick Overview for APC2 抗体 (AA 2041-2181) (ABIN5611232)
抗原
See all APC2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 2041-2181
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原理
- APC2 Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human APC2 (AA: 2041-2181) expressed in E. Coli.
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亚型
- IgG1
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anti-APC Regulator of WNT Signaling Pathway 2 (APC2) (AA 849-898) antibody
APC2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-APC Regulator of WNT Signaling Pathway 2 (APC2) (AA 2011-2221) antibodyAPC2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-APC Regulator of WNT Signaling Pathway 2 (APC2) (AA 122-152) antibodyAPC2 适用: 人 WB 宿主: 兔 Polyclonal RB53935 unconjugated
anti-APC Regulator of WNT Signaling Pathway 2 (APC2) (Middle Region) antibodyAPC2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))
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别名
- APC2
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背景
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This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms.
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分子量
- 244 kDa
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UniProt
- O95996
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途径
- WNT signaling
抗原
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