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GCLC 抗体 (AA 528-637)

Cited in 6+ publications. This 小鼠 单克隆 anti-GCLC antibody (Clone 3H1) specifically detects GCLC in WB, ELISA 和 IF. The antibody is reactive with 人 samples.
产品编号 ABIN561050
发货至: 中国
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中国
北京 101111
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Room 801-803
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Quick Overview for GCLC 抗体 (AA 528-637) (ABIN561050)

抗原

See all GCLC 抗体
GCLC (Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This GCLC antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunofluorescence (IF)

克隆位点

3H1
  • 抗原表位

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    AA 528-637

    原理

    Mouse monoclonal antibody raised against a partial recombinant GCLC.

    序列

    EGVFPGLIPI LNSYLENMEV DVDTRCSILN YLKLIKKRAS GELMTVARWM REFIANHPDY KQDSVITDEM NYSLILKCNQ IANELCECPE LLGSAFRKVK YSGSKTDSSN

    交叉反应

    人, 小鼠, 大鼠

    产品特性

    Antibody Reactive Against Recombinant Protein.

    免疫原

    GCLC (NP_001489, 528 a.a. ~ 637 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

    亚型

    IgG1
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 缓冲液

    In 1x PBS, pH 7.4

    注意事项

    Aliquot to avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Sugiyama, Ebinuma, Nakamoto, Sakasegawa, Murakami, Chu, Usui, Ishibashi, Wakayama, Taniki, Murata, Saito, Fukasawa, Saito, Yamagishi, Wakita, Takaku, Hibi, Saito, Kanai: "Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus." in: PLoS ONE, Vol. 9, Issue 4, pp. e94460, (2014) (PubMed).

    Venè, Cardinali, Arena, Ferrari, Benelli, Minghelli, Poggi, Noonan, Albini, Tosetti: "Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress." in: Neoplasia (New York, N.Y.), Vol. 16, Issue 9, pp. 710-22, (2014) (PubMed).

    Li, Gunter, Fukagawa: "Differential activation of the inflammasome in THP-1 cells exposed to chrysotile asbestos and Libby "six-mix" amphiboles and subsequent activation of BEAS-2B cells." in: Cytokine, Vol. 60, Issue 3, pp. 718-30, (2012) (PubMed).

    Fan, Liu, Hao, Wang, Robinson, Monnier: "The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis." in: PLoS ONE, Vol. 7, Issue 11, pp. e50832, (2012) (PubMed).

    Abel, Bubel, Simper, Powell, McClellan, Andreeff, MacLeod, DiGiovanni: "Protection against 2-chloroethyl ethyl sulfide (CEES)-induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway." in: Toxicology and applied pharmacology, Vol. 255, Issue 2, pp. 176-83, (2011) (PubMed).

    Hardwick, Fisher, Canet, Lake, Cherrington: "Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 38, Issue 12, pp. 2293-301, (2010) (PubMed).

  • 抗原

    GCLC (Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))

    别名

    GCLC

    背景

    Full Gene Name: glutamate-cysteine ligase, catalytic subunit
    Synonyms: GCS,GLCL,GLCLC

    基因ID

    2729

    NCBI登录号

    NM_001498

    途径

    Cell RedoxHomeostasis
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