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Clusterin 抗体

Name: Clusterin 抗体
SKU: ABIN5596991
Availability: OutOfStock

CLU 适用: 人 WB, IHC, ELISA, IP 宿主: 山羊 Polyclonal unconjugated

Western Blot of Anti-Apolipoprotein J Antibody. (Clusterin 抗体)

2 images

(1 reference)

产品编号 ABIN5596991

Supplier Product No.: 600-101-198

发货至: 中国

Datasheet as PDF

抗原 See all Clusterin (CLU) 抗体

Clusterin (CLU)
适用
89

28

28

12

7

6

2

1

1

1
人
宿主
83

39

7

4

2

1

1
山羊
Compatible Secondaries
克隆类型
95

40

1
多克隆
标记
80

25

17

3

3

2

1

1

1

1

1

1

1
This Clusterin antibody is un-conjugated
应用范围
111

67

58

22

22

20

17

11

8

6

6

5

3

2

1

1

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Supplier Product No.

600-101-198

Supplier

Rockland

原理

APOLIPOPROTEIN J Antibody

交叉反应（详细）

Typically less than 1 % cross reactivity against other types of apoLipoprotein was detected by ELISA against purified standards.

产品特性

Synonyms: goat anti-Apolipoprotein J antibody, Clusterin, Complement-associated protein SP-40, Complement cytolysis inhibitor, CLI, NA1/NA2, Apo-J, Testosterone-repressed prostate message 2, TRPM-2, Ku70-binding protein 1, Aging-associated gene 4 protein, Clusterin beta chain, Clusterin alpha chain, Complement cytolysis inhibitor a chain, Complement cytolysis inhibitor b chain, ApoJ alpha, ApoJ beta, CLU, CLI, KUB1, AAG4

纯化方法

This product has been prepared by immunoaffinity chromatography using immobilized antigens followed by extensive cross-adsorption against other apoLipoproteins and human serum proteins to remove any unwanted specificities.

过滤

Sterile filtered

免疫原

Immunogen: apoLipoprotein Type J was isolated from human plasma by density gradient centrifugation followed by HPLC purification.
Immunogen Type: Native Protein

亚型

IgG

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CLU 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

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CLU 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated

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CLU 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A11 unconjugated

anti-Clusterin (CLU) (Internal Region) antibody
CLU 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Immunohistochemistry Dilution: 1:50 - 1:200
Application Note: Anti-apolipoprotein antibodies have been used for indirect trapping ELISA for quantitation of antigen in serum using a standard curve, for immunoprecipitation and for western blotting for highly sensitive qualitative analysis.
Western Blot Dilution: 1:5,000 - 1:10,000
Immunoprecipitation Dilution: 1:100
ELISA Dilution: 1:5,000 - 1:10,000
Other: User Optimized

限制

仅限研究用
状态

Liquid

浓度

1.0 mg/mL

缓冲液

Buffer: 0.125 M Sodium Borate, 0.075 M Sodium Chloride, 0.005 M EDTA, pH 8.0
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store vial at 4° C prior to opening. This product is stable at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage mix with an equal volume of glycerol, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing.

有效期

12 months
Hayashi, Campenot, Vance, Vance: "Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cgamma1 and inhibition of calcineurin." in: The Journal of biological chemistry, Vol. 284, Issue 43, pp. 29605-13, (2009) (PubMed).
抗原

Clusterin (CLU)

别名

CLU (CLU 产品)

背景

Background: Apolipoprotein J Antibody functions as a secreted chaperone that prevents aggregation of nonnative proteins. It prevents stress-induced aggregation of blood plasma proteins and inhibits the formations of amyloid fibrils. Apolipoprotein J does not require ATP or refold proteins by itself. It maintains partially unfolded proteins in a state for subsequent refolding by other chaperones. It is shown to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Binding to cell surface receptors it triggers internalization of chaperone-client complex and subsequent lysosomal or proteasomal degradation. It modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis while mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Anti-Apolipoprotein J Antibody is useful for researchers interested in the immune system, Ubiquitin pathways, and cardiovascular research.

基因ID

1191

NCBI登录号

NP_001822

UniProt

P10909

途径

Apoptosis, Negative Regulation of intrinsic apoptotic Signaling