C19ORF80 抗体
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北京 101111
Quick Overview for C19ORF80 抗体 (ABIN5564288)
抗原
See all C19ORF80 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Recognizes human betatrophin.
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交叉反应
- 人
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免疫原
- Recombinant human betatrophin.
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anti-Chromosome 19 Open Reading Frame 80 (C19ORF80) (AA 24-196) antibody
C19ORF80 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 19 Open Reading Frame 80 (C19ORF80) (AA 16-198) antibodyC19ORF80 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 19 Open Reading Frame 80 (C19ORF80) (AA 22-198) antibodyC19ORF80 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 19 Open Reading Frame 80 (C19ORF80) (AA 24-196) antibodyC19ORF80 适用: 人 WB 宿主: 小鼠 Monoclonal D3 unconjugated
anti-Chromosome 19 Open Reading Frame 80 (C19ORF80) (AA 1-251) antibodyC19ORF80 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
有效期
- 12 months
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: "Transplantation of betatrophin-expressing adipose-derived mesenchymal stem cells induces β-cell proliferation in diabetic mice." in: International journal of molecular medicine, Vol. 39, Issue 4, pp. 936-948, (2017) (PubMed).
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: "Transplantation of betatrophin-expressing adipose-derived mesenchymal stem cells induces β-cell proliferation in diabetic mice." in: International journal of molecular medicine, Vol. 39, Issue 4, pp. 936-948, (2017) (PubMed).
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- C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))
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别名
- Betatrophin
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背景
- Betatrophin (RIFL, Lipasin, Angiopoietin-like protein 8 (ANGPTL8)) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. Betatrophin may also function in inhibition of lipase activity and on serum triglyceride regulation. Betatrophin is expressed in the liver and in white and brown adipose tissue of mice. In humans, betatrophin is found to be predominantly expressed in the liver. Betatrophin levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. Betatrophin, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8/Betatrophin does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.
抗原
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