NLRC3 抗体
This 小鼠 单克隆 anti-NLRC3 antibody (Clone Eowyn-1) specifically detects NLRC3 in WB. The antibody is reactive with 小鼠 samples.
产品编号 ABIN5564287
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for NLRC3 抗体 (ABIN5564287)
抗原
See all NLRC3 抗体
NLRC3
(NLR Family, CARD Domain Containing 3 (NLRC3))
适用
小鼠
宿主
小鼠
克隆类型
单克隆
标记
This NLRC3 antibody is un-conjugated
应用范围
Western Blotting (WB)
克隆位点
Eowyn-1
-
-
特异性
- Detects overexpressed mouse NLRC3. Doest not detect human NLRC3. Although NLRC3 (mouse), mAb (Eowyn-1) is strong and specific (see figure), the endogenous protein has not been detected yet with this antibody (using NLRC3 KO versus WT immune cells). NLRC3 protein is probably expressed at very low levels or its translation / stability is triggered by stimuli still to be discovered .
-
交叉反应
- 小鼠
-
纯度
- >95 % (SDS-PAGE)
-
免疫原
- Recombinant mouse NLRC3 (card domain).
-
亚型
- IgG1
-
-
anti-NLR Family, CARD Domain Containing 3 (NLRC3) (Internal Region) antibody
NLRC3 适用: 小鼠, 人, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, CARD Domain Containing 3 (NLRC3) (Center) antibodyNLRC3 适用: 小鼠, 人, 大鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
-
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- Lot specific
-
缓冲液
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
有效期
- 12 months
-
-
- NLRC3 (NLR Family, CARD Domain Containing 3 (NLRC3))
-
别名
- NLRC3
-
背景
- The novel nucleotide oligomerization domain (NOD)-like receptor (NLR) with a caspase activation and recruitment domain (CARD) 3 (NLRC3) protein belongs to the NLR family of cytosolic pathogen recognition receptors. NLRC3 has the characteristic NOD and leucine-rich repeat configuration with a less well defined CARD. NLRC3 is expressed in T lymphocytes and may be involved in suppression of T cell activation. NLRC3 is a cytoplasmic protein that negatively regulates pro-IL-1beta maturation and inhibits toll-like receptor (TLR)-dependent activation of the transcription factor NF-kappaB. NLRC3 interacts with the TLR signaling adaptor TRAF6 to attenuate Lys63 (K63)-linked ubiquitination of TRAF6 and activation of NF-kappaB. NLRC3 also reduces STING-dependent innate immune activation in response to cytosolic DNA, cyclic di-GMP (c-di-GMP) and DNA viruses. NLRC3 associated with both STING and TBK1, impedes STING-TBK1 interaction and downstream type I interferon production.
-
UniProt
- Q5DU56
抗原
-
You are here:
