IL1F9 抗体
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北京 101111
Quick Overview for IL1F9 抗体 (ABIN5564239)
抗原
See all IL1F9 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- anti-IL-36gamma (human), mAb (Jussy-1)
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特异性
- Recognizes human IL-36gamma.
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产品特性
- Monoclonal Antibody. Recognizes human IL-36gamma. Isotype: Mouse IgG1kappa. Clone: Jussy-1. Applications: ELISA, WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells, thus promoting neutrophil influx, dendritic cell (DC) activation, polarization of T helper type 1 (Th1) and IL-17-producing T cells (alphabeta T cells and gammadelta T cells) and keratinocyte proliferation. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. IL-36gamma is also induced in the lung in various models of asthma and can be produced by bronchial epithelial cells in response to viral infection, smoke or inflammatory cytokines.
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纯度
- >95 % (SDS-PAGE)
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免疫原
- Recombinant human IL-36gamma.
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亚型
- IgG1 kappa
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anti-Interleukin 1 Family Member 9 (IL1F9) antibody
IL1F9 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 6E4 unconjugated
anti-Interleukin 1 Family Member 9 (IL1F9) (AA 5-149) antibodyIL1F9 适用: 小鼠 WB 宿主: 小鼠 Monoclonal D2 unconjugated
anti-Interleukin 1 Family Member 9 (IL1F9) (AA 1-169) antibodyIL1F9 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 1 Family Member 9 (IL1F9) (C-Term) antibodyIL1F9 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 1 Family Member 9 (IL1F9) (AA 1-110) antibodyIL1F9 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2A8 unconjugated
anti-Interleukin 1 Family Member 9 (IL1F9) (AA 5-149) antibodyIL1F9 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 1 Family Member 9 (IL1F9) (AA 1-162) antibodyIL1F9 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 1 Family Member 9 (IL1F9) (AA 1-158) antibodyIL1F9 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
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+4°C
-20°C
Stable for at least 1 year after receipt when stored at -20°C.
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有效期
- 12 months
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- IL1F9 (Interleukin 1 Family Member 9 (IL1F9))
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别名
- IL-36gamma
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背景
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Alternate Names/Synonyms: Interleukin-36gamma, Interleukin-1 Family Member 9, IL-1F9
Product Description: IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells, thus promoting neutrophil influx, dendritic cell (DC) activation, polarization of T helper type 1 (Th1) and IL-17-producing T cells (alphabeta T cells and gammadelta T cells) and keratinocyte proliferation. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. IL-36gamma is also induced in the lung in various models of asthma and can be produced by bronchial epithelial cells in response to viral infection, smoke or inflammatory cytokines.
抗原
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