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Nanog 抗体

This anti-Nanog antibody is a 兔 单克隆 antibody detecting Nanog in WB. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN5557500
发货至: 中国

Quick Overview for Nanog 抗体 (ABIN5557500)

抗原

See all Nanog (NANOG) 抗体
Nanog (NANOG) (Nanog Homeobox (NANOG))

适用

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人, 小鼠, 大鼠

宿主

  • 131
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克隆类型

  • 122
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单克隆

标记

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This Nanog antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

1A11
  • 交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein A.

    免疫原

    Recombinant human Nanog protein, around N-terminal 1-100aa.

    亚型

    IgG
  • 应用备注

    WB 1:300-5000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    有效期

    12 months
  • 抗原

    Nanog (NANOG) (Nanog Homeobox (NANOG))

    别名

    Nanog

    背景

    Synonyms: Homeobox protein NANOG, NANOG

    Background: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.

    基因ID

    79923

    UniProt

    Q9H9S0

    途径

    Stem Cell Maintenance
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