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FOXP1 抗体

FOXP1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Monoclonal 15E2 unconjugated
产品编号 ABIN5557471
发货至: 中国
  • 抗原 See all FOXP1 抗体
    FOXP1 (Forkhead Box P1 (FOXP1))
    适用
    • 73
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    人, 小鼠, 大鼠
    宿主
    • 78
    • 12
    • 2
    克隆类型
    • 68
    • 23
    • 1
    单克隆
    标记
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    This FOXP1 antibody is un-conjugated
    应用范围
    • 44
    • 37
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    • 12
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    Western Blotting (WB)
    纯化方法
    Purified by Protein A.
    免疫原
    Recombinant human FOXP1 protein, around C-terminal 150aa.
    克隆位点
    15E2
    亚型
    IgG
    Top Product
    Discover our top product FOXP1 Primary Antibody
  • 应用备注
    WB 1:1000-5000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    储存条件
    -20 °C
    储存方法
    Store at -20°C
    有效期
    12 months
  • 抗原
    FOXP1 (Forkhead Box P1 (FOXP1))
    别名
    FOXP1 (FOXP1 产品)
    背景

    Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program, the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity, may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence, the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions, repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis, the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093).

    Synonyms: Forkhead box protein P1, FOXP1

    基因ID
    27086
    UniProt
    Q9H334
    途径
    Chromatin Binding, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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