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Cyclin D3 抗体

CCND3 适用: 人 WB, IF (cc) 宿主: 兔 Monoclonal 4A8 unconjugated
产品编号 ABIN5557294
发货至: 中国
  • 抗原 See all Cyclin D3 (CCND3) 抗体
    Cyclin D3 (CCND3)
    适用
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    宿主
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    克隆类型
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    单克隆
    标记
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    This Cyclin D3 antibody is un-conjugated
    应用范围
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    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))
    交叉反应
    纯化方法
    Purified by Protein A.
    免疫原
    Recombinant human Cyclin D3 protein, around C-terminal 200aa.
    克隆位点
    4A8
    亚型
    IgG
    Top Product
    Discover our top product CCND3 Primary Antibody
  • 应用备注
    WB 1:300-5000
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    Cyclin D3 (CCND3)
    别名
    Cyclin D3 (CCND3 产品)
    别名
    zgc:103502 antibody, CCND3 antibody, 9230106B05Rik antibody, AA682053 antibody, AL024085 antibody, AW146355 antibody, C78795 antibody, cyclin D3 antibody, ccnd3 antibody, CCND3 antibody, Ccnd3 antibody
    背景

    Synonyms: G1/S-specific cyclin-D3, CCND3

    Background: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

    基因ID
    896
    UniProt
    P30281
    途径
    Cell Division Cycle, Mitotic G1-G1/S Phases, Glycosaminoglycan Metabolic Process
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