ACVR1 抗体 (AA 21-120)
Quick Overview for ACVR1 抗体 (AA 21-120) (ABIN5542584)
抗原
See all ACVR1 (ACRV1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 21-120
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原理
- ACVR1 Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human ACVR1 (AA: 21-120) expressed in E. Coli.
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亚型
- IgG1
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))
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别名
- ACVR1
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背景
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Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
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分子量
- 57.2 kDa
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UniProt
- Q04771
抗原
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