PKN1 抗体 (AA 442-620)
Quick Overview for PKN1 抗体 (AA 442-620) (ABIN5542353)
抗原
See all PKN1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 442-620
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原理
- PKN1 Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human PKN1 (AA: 442-620) expressed in E. Coli.
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亚型
- IgG2b
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- PKN1 (Protein Kinase N1 (PKN1))
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别名
- PKN1
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背景
- The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
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分子量
- 104 kDa
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基因ID
- 5585
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UniProt
- Q16512
抗原
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