CR1L 抗体
This anti-CR1L antibody is a 大鼠 单克隆 antibody detecting CR1L in EIA. Suitable for 小鼠.
Quick Overview for CR1L 抗体 (ABIN5542182)
抗原
See all CR1L 抗体
CR1L
(Complement Component (3b/4b) Receptor 1-Like (CR1L))
适用
小鼠
宿主
大鼠
克隆类型
单克隆
标记
This CR1L antibody is un-conjugated
应用范围
Enzyme Immunoassay (EIA)
克隆位点
8A-E6
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特异性
- The monoclonal antibody 8A/E6 recognizes Mouse complement receptor type-1 related gene Y (Crry/p65), a type I membrane protein (MW 56-60 kDa).
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纯化方法
- Purified
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免疫原
- Mouse Crry fused to Mouse IgG2a-Fc
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亚型
- IgG1
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anti-Complement Component (3b/4b) Receptor 1-Like (CR1L) (AA 51-150) antibody
CR1L 适用: 小鼠 WB, IF (cc), IF (p), IHC (fro), ELISA, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component (3b/4b) Receptor 1-Like (CR1L) (AA 57-106) antibodyCR1L 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Immuno assays.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Buffer System: PBS Preservatives: 0.02 % Sodium Azide Stabilizers: 0.1 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
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有效期
- 12 months
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- CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))
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别名
- cr1l,crry
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背景
- Complement comprises a system of soluble serum proteins that, upon activation by antibody (classical pathway), sugars (lectin pathway), or bacterial and foreign surfaces (alternative pathway), directly causes cell damage. Complement is constantly activated at low levels in serum, requiring cells to protect themselves from damage. In human, cells are protected from complement-mediated damage by expression of membrane-bound complement regulatory proteins, which act at serveral points along the cascade. Human cells are protected by decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and membrane attack complex inhibitor protein 1 (MIN1, CD59). Rat and mouse express a unique membrane complement regulator of the activating pathways, called complement receptor type-1 related gene Y (Crry). Crry/p65 is expressed on a wide variety of cells. Crry/p65 contains tandem short consensus repeats (SCR) characteristic of C3/C4 binding proteins. Mouse Crry/p65 has been shown to regulate both classical and alternative complement pathway C3 deposition on cell membranes. Crry/p65 must, therefore, exert its effects prior to, or at the level of, the C3 convertases, in a fashion similar to that of the human membrane factors DAF and MCP. Crry/p65 is an evolutionarily unique, complement regulatory protein which has developed in mouse and rat. Besides the involvement in control of complement damage to cell membranes Crry has also a role in T cell activation. Crry basically enhances the signals triggered by TCR/CD3 activation.
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UniProt
- Q64735
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途径
- Complement System
抗原
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