LGR4 抗体
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北京 101111
Quick Overview for LGR4 抗体 (ABIN5541954)
抗原
See all LGR4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognizes LGR4 / GPR48. Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.
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纯化方法
- Affinity Chromatography on Protein G
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免疫原
- cDNA encoding Human LGR4
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亚型
- IgG2a
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应用备注
- Flow cytometry: 1.2 μg/10 6 cells. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.2
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储存条件
- 4 °C,-20 °C
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储存方法
- Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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有效期
- 12 months
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- LGR4 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4))
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别名
- lgr4,gpr48
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背景
- LGR4 (Leucine-rich repeat- containing G protein-coupled receptor 4) belongs to the superfamily of G protein-coupled receptors (GPCRs). It is a 951 amino acid multi-pass membrane protein and has multiple N-terminal leucine-rich repeats, which are important for interaction with the glycoprotein ligands, and 7 transmembrane domains (1,3). LGR4 is highly expressed in the adult human pancreas but also with moderate levels of expression in placenta, kidney, brain and heart (2). LGR4 functions as an orphan receptor that may be involved in physiologic activities throughout the cell. It is overexpressed in various cancer types and is thought to enhance carcinoma invasiveness and metastasis, suggesting an important role in tumor progression.
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UniProt
- Q9BXB1
抗原
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