CD81 抗体
Quick Overview for CD81 抗体 (ABIN5541933)
抗原
See all CD81 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
特异性
- Recognizes Human CD81. Other species not tested. Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.
-
纯化方法
- Affinity Chromatography on Protein G
-
免疫原
- cDNA encoding Human CD81
-
亚型
- IgG2b
-
-
-
-
应用备注
- Flow Cytometry: 1.2 μg/10 6 cells. ELISA: 1/200-1/400. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS, pH 7.2
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
-
有效期
- 12 months
-
-
- CD81
-
别名
- cd81,tapa1
-
背景
- CD81 (TAPA-1) belongs to the transmembrane 4 superfamily (tetraspanin family). CD81 is a widely expressed cell-surface protein that is characterized by the presence of four transmembranic domains, short N and C termini, a small extracellular loop (SEL) and a large extra-cellular loop (LEL) (1). It is expressed on cells of hematopoietic, neuroectodermal and mesenchymal origin and plays a role in the regulation of cell development, cell-growth and signal transduction. CD81 plays a critical role in Hepatitis C Infection and is involved in HCV entry due to its ability to interact with virus' E1/E2 glycoproteins (2,3). CD81 is an essential HCV host factor as silencing of CD81 expression by CD81-specific monoclonal antibodies in hepatoma cells inhibits HCV entry (4).
-
UniProt
- P60033
-
途径
- Inositol Metabolic Process, Hepatitis C
抗原
-