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CD81 抗体

CD81 适用: 人 FACS, cELISA 宿主: 大鼠 Monoclonal QV-6A8-S3 unconjugated
产品编号 ABIN1720914
发货至: 中国
  • 抗原 See all CD81 抗体
    CD81
    适用
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    大鼠
    克隆类型
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    单克隆
    标记
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    This CD81 antibody is un-conjugated
    应用范围
    • 116
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    Flow Cytometry (FACS), Cell-ELISA (cELISA)
    特异性
    Anti-human CD81 (TAPA-1)
    产品特性
    Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells
    纯化方法
    Protein G
    免疫原
    genetic immunisation with cDNA encoding human CD81
    克隆位点
    QV-6A8-S3
    亚型
    IgG2b
    Top Product
    Discover our top product CD81 Primary Antibody
  • 应用备注
    Flow cytometry: 1.2 µg/10^6 cells
    ELISA: 1:200 - 1:400
    CELISA: 1:200 - 1:400
    For each application a titration should be performed to determine the optimal concentration.
    说明

    Synonyms: TAPA-1

    限制
    仅限研究用
  • 缓冲液
    PBS, pH 7.2
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C
    储存方法
    short term: 2 °C - 8 °C, long term: -20 °C
  • Fofana, Xiao, Thumann, Turek, Zona, Tawar, Grunert, Thompson, Zeisel, Baumert: "A novel monoclonal anti-CD81 antibody produced by genetic immunization efficiently inhibits Hepatitis C virus cell-cell transmission." in: PLoS ONE, Vol. 8, Issue 5, pp. e64221, (2013) (PubMed).

  • 抗原
    CD81
    别名
    CD81 (CD81 产品)
    别名
    Tapa-1 antibody, Tapa1 antibody, Tspan28 antibody, CVID6 antibody, S5.7 antibody, TAPA1 antibody, TSPAN28 antibody, CD81 molecule antibody, CD81 molecule b antibody, CD81 antigen antibody, Cd81 molecule antibody, CD81 antibody, cd81b antibody, Cd81 antibody
    背景
    CD81 (TAPA-1) belongs to the transmembrane 4 superfamily (tetraspanin family). CD81 is a widely expressed cell-surface protein that is characterized by the presence of four transmembranic domains, short N and C termini, a small extracellular loop (SEL) and a large extra-cellular loop (LEL). It is expressed on cells of hematopoietic, neuroectodermal and mesenchymal origin and plays a role in the regulation of cell development, cell-growth and signal transduction. CD81 plays a critical role in Hepatitis C Infection and is involved in HCV entry due to its ability to interact with virus' E1/E2 glycoproteins. CD81 is an essential HCV host factor as silencing of CD81 expression by CD81-specific monoclonal antibodies in hepatoma cells inhibits HCV entry.
    UniProt
    P60033
    途径
    Inositol Metabolic Process, Hepatitis C
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