TWEAK 抗体
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北京 101111
Quick Overview for TWEAK 抗体 (ABIN5541911)
抗原
See all TWEAK (TNFSF12) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antobody recognizes CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to weakly induce apoptosis in many cell types.
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纯化方法
- Protein-A affinity chromatography
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免疫原
- Human CD255-transfected 2PK-3 cells
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亚型
- IgG3
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应用备注
- Flow cytometry. Functional application: Neutralization.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Phosphate buffered saline (PBS) Preservatives: 15 mM sodium azide, approx. pH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
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有效期
- 12 months
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- TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))
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别名
- tweak,tnfsf12
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背景
- CD255 / TWEAK (TNF-related weak inducer of apoptosis), a type II transmembrane protein expressed as membrane-bound and secreted form, can induce apoptosis in many tissues and cell lines through its receptor CD266 / TWEAK R. On the other hand, in endothelial cells this interaction can induce proliferation and promote angiogenesis including neovascularization of tumours. CD255 can act in a juxtacrine manner to initiate cellular responses, and induces secretion of pro-inflammatory cytokines. Besides CD266, CD255 may also bind to DR3.
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UniProt
- O43508
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途径
- Apoptosis
抗原
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