JAK2 抗体
Quick Overview for JAK2 抗体 (ABIN5541875)
抗原
See all JAK2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody reacts with the 130 kDa JAK2 on human and other species with consensus sequence.
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纯化方法
- Protein G affinity
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免疫原
- Synthetic peptide derived from the human JAK2 peptide, conjugated with KLH
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anti-Janus Kinase 2 (JAK2) (pTyr1007), (pTyr1008) antibody
JAK2 适用: 人, 大鼠, 小鼠, 兔, 斑马鱼 WB, ELISA, FACS, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (AA 508-800) antibodyJAK2 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (AA 916-1103) antibodyJAK2 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (AA 745-955) antibodyJAK2 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 5C12C9 unconjugated
anti-Janus Kinase 2 (JAK2) (pTyr221) antibodyJAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (pTyr931) antibodyJAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (pTyr1007), (pTyr1008) antibodyJAK2 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Monoclonal 1A4 unconjugated Recombinant Antibody
anti-Janus Kinase 2 (JAK2) (C-Term) antibodyJAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (AA 1101-1132) antibodyJAK2 适用: 人, 小鼠 WB, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (N-Term) antibodyJAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA: 1/64,000 for detection of the JAK2 peptide coated on ELISA plate. Western blot: 1/2,000 to detect 130 kDa JAK2 in TF-1 cell extract.
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限制
- 仅限研究用
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缓冲液
- 0.01M PBS, pH 7.4
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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有效期
- 12 months
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- JAK2 (Janus Kinase 2 (JAK2))
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别名
- tyrosine-protein kinase jak2
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背景
- Janus kinase 2 (JAK2) is a non-receptor tyrosine kinase that plays an important role in signal transduction through its association with receptors on the cell membrane. When these receptors are activated by extracellular signals, the receptors activate JAK2 which in turn phosphorylates the tyrosine residues on the receptors. The phosphorylation enables the binding of downstream signaling molecules, primarily, signal transducer and activator of transcription (STAT) proteins. STATs possess a SHdomain that specifically binds to phosphorylated tyrosine residue on the receptor. STAT in cytoplasma is activated after binding and migrates to nucleus to activate gene transcription. JAK2 mediates the transduction of a variety of extracellular signals in this pattern. The receptors that are associated with JAK2 include type II cytokine receptors, GM-CSF receptor family, gp130 receptor family, growth hormone receptor, prolactin receptor and EPO receptor.
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UniProt
- O60674
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途径
- JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded Protein Response
抗原
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